缬草素抗焦虑活性研究

Anxiolytic Activity of Valeportiate

摘要:

目的 :研究缬草素的抗焦虑作用。 方法: 雄性SD 大鼠60 只,随机分为5 组:缬草素高、中、低剂量组(剂量分别为20,10,5 mg ·kg^-1)、阳性药地西泮(diazepam, DZP)组和空白组,ig 10 d 后采用国际通用的高架十字迷宫(elevated plus maze, EPM)焦虑动物模型,从行为学角度观察了缬草素的抗焦虑作用。 结果: EPM 行为学观察表明:与空白组相比,DZP和缬草素中剂量组可明显提高大鼠在开臂时间百分率(14.07%, 38.09%, 37.42%,P<0.01)和次数百分率(16.98%, 30.10%, 37.19%, P<0.05 或 P<0.01)。 结论: 缬草素有明显的抗焦虑作用。

Abstract:

Objective: To study anxiolytic activity of valeportriate isolated from the root of Valeriana jatamansi. Method: Sixty Sprague-Dawley rats were randomly divided into 5 groups for daily intragastric administration of drugs: valeportriate high-dose (20 mg ·kg^-1), valeportriate medium-dose (10 mg ·kg^-1), valeportriate low-dose (5 mg ·kg^-1), the positive drug group and normal control group, treated ig for 10 days. Adopting the international common-used anxiety animal model with the elevated plus-maze test (EPM),we observed the effect of anti-anxiety of valeportiate from the angle of behavior. Result: The results of EPM showed that DZP and valeportriate medium-dose group obviously increased the percentages of open arm time (14.07%, 38.09%, 37.42%, P<0.01) and entry (16.98%, 30.10%, 37.19%, P<0.05 or P<0.01) comparing with control group. Conclusion: Valeportriate has obvious anti-anxiety activity.