芒果苷单钠盐的抑菌作用研究

Bacteriostatic Action of Mangoferin Monosodium Salt

摘要:

目的: 观察芒果苷单钠盐的抑菌作用。 方法: 以咽喉及上呼吸道常见致病菌肺炎双球菌、肺炎克雷伯菌、金黄色葡萄球菌和流感嗜血杆菌为受试菌,分别通过体外抑菌和体内抑菌实验来观察芒果苷单钠盐的抑菌作用。 结果: 体外研究显示芒果苷单钠盐对肺炎双球菌、肺炎克雷伯菌、金黄色葡萄球菌和流感嗜血杆菌均表现出一定的抑制作用。其最小抑菌质量浓度分别为10.0,5.0,10.0,2.5 g ·L^-1。体内研究显示芒果苷单钠盐可显著提升菌液感染小鼠的存活率。 结论: 芒果苷单钠盐具有明显的抑菌作用。

Abstract:

Objective: To investigate the bacteriostatic action of mangoferin monosodium salt. Method: Bacteriostasis in vivo and in vitro experiments for Diplococcus pennmoniae,Klebsiella pneumoniae,Staphylococcus aureus,Haemophilus influenzae was examined respectively to observe the antibiosis effect of mangoferin monosodium salt. Result: Mangoferin monosodium salt showed some extents of antibiosis effect to D.pennmoniae,K.pneumoniae,S.aureus,H.influenzae for in vitro experiment.The minimal inhibitory concentration (MIC) were 10.0,5.0,10.0,2.5 g ·L^-1,respectively.Mangoferin monosodium salt also showed significant in vivo protection effect in infected mouse. Conclusion: Mangoferin monosodium salt has good bacteriostatic action.