荆芥内酯的一般药理学研究

Study on General Pharmacology of Schizonepetin

摘要:

目的: 观察荆芥内酯(schizonepetin,ST)对实验动物心血管系统、中枢神经系统、呼吸系统的影响。 方法: 以不同剂量荆芥内酯给予小鼠(200,100,50 mg ·kg^-1)和大鼠(100,50,25 mg ·kg^-1)口服给药,观察荆芥内酯对小鼠入睡只数、自主活动和大鼠在转棒上掉落次数的影响;以不同剂量荆芥内酯(40,20,10 mg ·kg^-1)对麻醉犬十二指肠给药,观察荆芥内酯对犬的呼吸频率、呼吸幅度、舒张压(SAP)、收缩压(DAP)、心率(HR)、PR间期、QRS、QT间期、T波各指标的影响。 结果: 荆芥内酯ig给药对正常小鼠自主活动无明显影响,并与小鼠戊巴妥钠阈下催眠剂量无协同作用;对大鼠在转棒上掉落次数无明显影响;ST各剂量组对麻醉犬呼吸频率和呼吸幅度无明显影响,对心率、舒张压和动脉压无显著影响;对心电图PR,QRS,QT间期和T波无显著延长。 结论: 一般药理作用研究表明,实验用药小鼠高剂量200 mg ·kg^-1为LD₅₀的1/2,为临床成人拟用药剂量的20倍,犬用药高剂量为40 mg ·kg^-1及以下剂量,荆芥内酯单次给药对神经系统、呼吸系统和心血管系统无明显影响。

Abstract:

Objective: To investigate whether schizonepetin has any influences on the cardiovascular system, the nervous system and the respiratory system of animals. Method: Mice and rats were given oral medicine with different doses of ST in order to evaluate the effects of ST on sleep and the autonomous movement in rats, on the falling number of mice from the rotating stick. Anesthetized dogs were given oral medicine with different doses of ST in order to evaluate the effects of ST on the frequency and depth of respiration, systolic and diastolic blood pressure (SAP, DAP), heart rate (HR), PR, QRS, QT and T-wave. Result: With the dosage, ST had no obvious effect on the number of sleep and the autonomous movement in rats,on the falling number of mice from the rotating stick. With the dosage, ST had no obvious effect on the frequency and depth of respiration, systolic and diastolic blood pressure, heart rate, PR,QRS,QT and T-wave. Conclusion: Experimental dosage for mice, 20 times of the clinical adult dosage, is the half dose of LD₅₀ for mice. The study indicates that at this level of dosage ST has no obvious effects on respiratory, cardiovascular and nervous systems.