颈动脉注射磷酸川芎嗪治疗脑梗死

Clinical Study on Carotid Artery Injection of Ligustrazine Phosphate Injection for Cerebral Infarction

摘要:

目的 :观察颈动脉注射磷酸川芎嗪注射液治疗脑梗死的临床疗效。 方法: 经过临床筛选,将年龄在45~65岁的240例脑梗死患者随机分为治疗组(120例)及对照组(120例),治疗组为一般治疗方法＋颈动脉注射,对照组为单纯一般治疗方法＋静脉滴注磷酸川芎嗪。分别检测实验组和对照组治疗前后的综合疗效、神经功能缺损积分、梗死面积等。 结果: 颈动脉注射治疗组对于脑梗死的患者120例总有效率94.2%(113/120)。对照组120例,总有效率85.8%(103/120)。 结论: 颈动脉注射磷酸川芎嗪注射液能降低神经功能缺损积分,明显缩小梗死面积;病程越短,疗效越好;安全性指标治疗前后差异无显著性。

Abstract:

Objective: To study the clinical efficacy of carotid artery injection of ligustrazine phosphate injection for treatment of cerebral infarction. Method: Two-hunrend and fourty patients (45 to 65 years) surffered from cerebal infarction were randomized into treatment group (120 cases) and control group (120 cases). Treatment group was taken with the convientional treatment supplemented with carotid artery injection of ligustrazine phosphate, and the control group was only taken convientional treatment supplemented with vein injection of ligustrazine phosphate. Two groups were observed with integrated effects, neurological deficit score, area of cerebral infarction etc, before and after treatment. Result: The total effective rate of carotid artery injection was 94.2% (113/120). The total effective rate of the control group was 85.8% (103/120). No case with adverse reactions was found in treatment group. The neurological deficit score and area of cerebral infarction in the treatment group was better than that in the control group (P＜0.05). The shorter the disease history, the better the treatment showed. Conclusion: Carotid artery injection of phosphate ligustrazine can reduce neurological deficit score and area of cerebral infarction.