老年性痴呆疾病模型的建立

Methods for Model Establishment of Alzheimer’s Disease

摘要:

整理近年来老年性痴呆(alzheimer’s disease, AD)动物模型相关资料,介绍AD模型的建立方法:物理的损伤方法建立AD模型、化学损伤建立AD模型、多因素综合致病模型、转基因AD动物、自然衰老AD动物等。通过文献整理发现,AD模型建立方法多样,每一动物或细胞模型都各有其优缺点,且建模机制不同,研究者应根据个人研究需要选择和建立合适的AD动物及细胞模型。

Abstract:

The alzheimer disease (AD) pathological models were collected to provide new ideas and methods, including main methods for establishing AD model, i.e. the physical methods, the chemical methods the multi-factors methods, transgenic AD model and natural aging AD model. From the data, we realized that there were many kinds of methods for AD establishment. Each model either at whole animal level or at cellular level has its advantages and disadvantages, with different underline mechanisms. Researchers should select the suitable method according to the need of their experiments.