糖皮质激素抵抗机制的研究进展

Pathogenesis Progress in Glucocorticoid Resistance

摘要:

糖皮质激素临床上常被用于治疗各种炎性疾病,但许多疾病都存在激素抵抗的现象。现代医学解释糖皮质激素抵抗的机制与激素代谢异常、受体基因改变、靶基因乙酰化/去乙酰化等环节有关;传统中医理论认为激素抵抗与肾阴、肾阳虚损有关。本文综述了糖皮质激素抵抗的现代和传统中医学理论的发病机制研究进展。

Abstract:

Glucocorticoid is an effective medicine to cure inflammatory disease in clinic, but the glucocorticoid resistance always takes place. Modern medicine thinks that the resistance has relevant with glucocorticoid metabolism, the gene change of glucocorticoid receptor and the histone acetylase and deacetylases of target gene, etc. On the other hand, Traditional Chinese medicine regards the resitance related with the yin and yang deficit of kidney. This review is to summarize the pathogenesis progress of glucocorticoid resistance in both modern medicine and traditional chinese medicine.