正交法配合药效指标综合筛选木香切制工艺

Optimization of Cutting Technology Associated with Pharmacodynamic Index for Aucklandiae Radix by Orthogonal Design

摘要:

目的: 优选木香的最佳切制工艺。 方法: 以木香烃内酯含量、去氢木香内酯含量、小鼠小肠炭末推进率为测定指标,以浸润加水量、浸润时间、切片厚度为考察因素,采用L₉(3⁴)正交设计表,综合加权评分法确定木香饮片最佳切制工艺。 结果: 最佳切制工艺为:净木香药材加入0.3倍量水,浸润10 h后切成1~2 mm薄片。 结论: 木香的最佳切制工艺合理可行,可为规范木香饮片质量标准提供参考。

Abstract:

Objective: to optimize the cutting technology of Aucklandiae Radix. Method: The cutting technology of Aucklandiae Radix was optimized by L₉ (3⁴) orthogonal design taking the content of costunolide and dehydrocostuslactone, the intestinal propulsion in mice as indexes with the amount of water, soaking time and thickness of pieces as factors. Result: The best cutting technology of Aucklandiae Radix was cutting 1-2 mm thin pieces after soaking 10 h with 0.3 times water. Conclusion: The optimum cutting technology of Aucklandiae Radix is reasonable and feasible; it can provide a reference for establishing the quality standard of Aucklandiae Radix pieces.