正交设计优选癌痛消颗粒的成型工艺

Selection on Optimal Molding Technology of Aitongxiao Granules by Orthogonal Design

摘要:

目的: 通过正交试验筛选出癌痛消颗粒的最佳成型工艺。 方法: 以颗粒的成型率、抗湿性及颗粒色泽均匀度为筛选指标,对影响颗粒制剂工艺的主要因素:混合辅料的组成比例、羧甲基纤维素钠(CMC-Na)用量及湿润剂乙醇体积分数等进行优化试验,采取正交设计L₉(3⁴)方法筛选出最佳成型工艺。 结果: 干浸膏粉中加入按糊精:可溶性淀粉(2 ∶1)比例组成的混合辅料,并加入2% CMC-Na,以85%乙醇做为湿润剂混合制粒为最佳工艺。 结论: 该处方制剂的成型率、抗湿性及颗粒色泽均匀度均较好,可为其生产提供科学的实验依据。

Abstract:

Objective: To select optimal molding technique of Aitongxiao granules by orthogonal design. Method: The main influential factors of the molding technique included the proportion between mixed subsidiary materials, CMC-NA dosage, ethanol concentration. Conditions of the molding were evaluated with formation rate, hygroscopic and color uniformity as indexes. The optimal technique of Aitongxiao granules was selected by L₉(3⁴) orthogonal design. Result: The best molding technique was that the proportion between mixed subsidiary materials (dextrin to soluble starch) was 2 ∶1, 2%CMC-NA, the wetting agent was 85% alcohol. Conclusion: The forming technology is feasible,stable,reasonable and reproducible and can serve as theoretic basis for industrial production.