抗血小板凝集药物三氟柳的合成

Synthesis of Antiplatelet Drug Triflusal 1*

摘要:

目的: 合成抗血小板凝集药物三氟柳。 方法: 以三氟甲基水杨酸为原料通过一步合成目标产物三氟柳。 结果: 目标化合物通过核磁、质谱、红外、元素分析等进行结构鉴定,通过HPLC分析其纯度达99.5%以上,总收率达65.4%。 结论: 该方法合成简单,方法可行,适合工业化生产。

Abstract:

Objective: To synthesis of the antiplatelet drug triflusal. Method: Triflusal was prepared from 4-trifluoro methyl salicylic acid by one step. Result: Its structure was confirmed by NMR, MS, IR, EA. The total yield of triflusal with the purity of 99.5% by HPLC was 65.4%. Conclusion: The synthetic route for triflusal was simple, feasible and convenient for industrial manufacture.