人参二味胶囊对糖尿病大鼠血糖、血脂的影响

Influence of Ginseng Two-ingredient Capsule on Blood Glucose and Blood Lipids in Diabetic Rats

摘要:

目的: 探讨人参二味胶囊对糖尿病大鼠血糖、血脂的影响。 方法: 60只SPF级雄性Wistar大鼠,体重为(180±20)g,普通饲料适应性喂养7 d。按随机数字表从中随机抽取10只作为正常组。其余50只用高脂饲料喂养4周后,给予30 mg ·kg^-1的链脲佐菌素(STZ) ip。将造模成功的大鼠按随机表分为4组,每组10只。其中3组分别ig人参二味胶囊、盐酸二甲双胍、参芪降糖颗粒共14 d,其余10只为模型组作为对照。ig前和ig 2周后各测1次空腹血糖和体重,最后从腹主动脉取血,化验各组大鼠的甘油三脂和胆固醇。评价人参二味胶囊对糖尿病大鼠血糖、血脂和体重的影响。 结果: 给药14 d后,人参二味胶囊能降低2型糖尿病大鼠的血糖和血脂,有效控制大鼠体重的降低,与模型组比较差异有统计学意义(P＜0.05)。 结论: 人参二味胶囊能降低2型糖尿病模型大鼠的血糖和血脂,有效控制大鼠体重的下降,但其降糖作用较盐酸二甲双胍和参芪降糖颗粒弱。

Abstract:

Objective: To study the influence of Ginseng Two-ingredient Capsule on blood glucose and blood lipids in the diabetic rats. Method: Sixty SPF male Wistar rats with the weight of (180±20) g were given normal forage adaptively for 7 days. Ten rats were selected randomly to form normal group. With high fat forage diet of four weeks, the rest 50 rats were injected with 30 mg ·kg^-1 of STZ intraperitioneally to establish rat model of diabetes. The model rats were randomly divided into model control group with 10 rats, Ginseng Two-ingredient Capsule group with 10 rats ig given the capsule, metformin hydrochloride group with 10 rats served metformin hydrochloride by way of ig, and Ginseng-Astragalus Hypoglycemic Granule group with 10 rats treated with Ginseng-Astragalus Hypoglycemic Granule by way of ig for 14 days. The fasting blood glucose and weight of the rats were measured before the treatments and after the treatments for two weeks. Blood sample was finally obtained from aorta of rats. Triglyceride and cholesterol were tested to evaluate the influence of Ginseng Two-ingredient Capsule on blood glucose, blood lipids, and the body weight in the diabetic rats was also investigated. Result: Fourteen days later after medicine treatment, Ginseng Two-ingredient Capsule could reduce blood sugar and blood lipids in the type 2 diabetic rats and control weight-reduction for rats effectively which have significant difference compared with that in the model group (P<0.05). Conclusion: Ginseng Two-ingredient Capsule can reduce blood sugar and blood lipids in type 2 diabetic rats and control weight-reduction for the rats effectively. However, its hypoglycemic effect was inferior to that of metformin or Ginseng-Astragalus hypoglycemic Granule.