固本益肾胶囊对小鼠免疫功能的影响

Effects of Guben Yishen Capsule on Immune Function in Mice 1*

摘要:

目的: 探讨固本益肾胶囊对小鼠免疫功能的影响。 方法: 昆明种小鼠,每组10只,随机分为正常对照组、模型组、贞芪扶正胶囊组(12.5 g ·kg^-1)、固本益肾胶囊高剂量组(4.5 g ·kg^-1)、固本益肾胶囊低剂量组(1.5 g ·kg^-1)。通过测定免疫抑制小鼠脾脏指数、胸腺指数、碳粒廓清吞噬指数(K)及校正吞噬指数(α)、血清溶血素水平、迟发型超敏反应(DTH)的影响,反映固本益肾胶囊对机体免疫功能的影响。 结果: 固本益肾胶囊可显著提高免疫抑制小鼠的脾脏指数及胸腺指数,升高碳粒廓清吞噬指数(P＜0.01)及校正吞噬指数(P＜0.05);提高血清溶血素水平(P＜0.01)及增强迟发型超敏反应(P＜0.01或P＜0.05)。 结论: 固本益肾胶囊对小鼠非特异性和特异性免疫功能有促进作用。

Abstract:

Objective: To study the effects of Guben Yishen Capsule(GB-C)on the immune function in mice. Method: Mice were divided into five groups. By the effect of the indexes of spleen and thymus,the level of serum hemolysin antibody,carbon particle clearance swallowing index,delayed type hypersensitivity(DTH)reflect the immune function. Result: GB-C can enhance the indexes of spleen and thymus,increase the number of K and α,improve the level of serum hemolysin antibody and the number of DTH was increased. Conclusion: GB-C can enhance the non-specific immunity and specific immunity function in mice.