东北刺人参茎叶提取物对环磷酰胺致免疫抑制小鼠免疫功能的影响

Efftect of Extracts from Stems and Leaves of Oplopanax elatus on Immune Functions in Immuno-suppressed Mice Induced by Cyclophosphamide

摘要:

目的: 评价东北刺人参茎叶提取物对免疫抑制模型小鼠免疫功能的影响。 方法: 实验小鼠分为空白对照组、环磷酰胺(CTX)模型组、东北刺人参茎叶提取物高、中、低剂量组(按生药量计为5.2,2.6,1.3 g ·kg^-1),空白对照组与模型组给予等量生理盐水,连续给药7 d,观察东北刺人参茎叶提取物对实验动物免疫器官脏器指数、碳粒廓清能力、迟发型超敏反应(DTH)的影响。 结果: 与模型组比较,东北刺人参茎叶提取物各剂量组均能显著提高小鼠免疫脏器指数、单核巨噬细胞的吞噬功能及小鼠DTH(P<0.05~P<0.01)。 结论: 东北刺人参茎叶提取物有提高免疫抑制小鼠免疫功能的作用。

Abstract:

Objective: To evaluate the effects of the extracts from stems and leaves of Oplopanax elatus on the immune functions of immune-suppressed mice by cyclophosphamide. Method: Mice were randomly divided into 5 groups: control group, model group, low, moderate and high dose groups (1.3, 2.6, 5.2 g ·kg^-1) of the extracts from stems and leaves of O. elatus. The mice were examined for immune organ weight index, carbon particle clearance capability of macrophage, delayed type hypersensitivity. Result: Compared with model group, all dose groups could significantly increase the weight of the immune organs, carbon particle clearance capability of macrophage and delayed type hypersensitivity(P<0.05-P<0.01). Conclusion: The extracts from stems and leaves of O. elatus can enhance the immune functions in immune-suppressed mice.