新生儿退黄合剂的剂型改良及临床疗效

Improvement of Dosage Form for Xinshenger Tuihuang Mixture and Clinical Observation on Neonatal Jaundice

摘要:

目的 :对新生儿退黄合剂进行剂型改良,改变给药途径,探讨其对新生儿黄疸的临床治疗效果。 方法: 采用水提醇沉法制备新生儿退黄合剂、新生儿退黄洗剂和灌肠液。将符合纳入标准的病例采用随机分组平行对照法,分为观察组A,B和对照组,各60例。对照组给予苯巴比妥钠口服;观察组A给予新生儿退黄合剂口服;观察组B退黄液灌肠同时给予退黄洗剂药浴。比较3组治疗有效率,检测血清胆红素,评价其退黄效果。 结果: 灌肠联合药浴组与对照组比治疗有效率提高,血清胆红素值下降,差异有统计学意义( P <0.01);与口服退黄合剂组相比总有效率提高( P <0.05)。 结论: 中药灌肠联合药浴治疗新生儿黄疸有效率高,同时克服了新生儿口服药物的不便,值得临床推广应用。

Abstract:

Objective: To improve the dosage form of Xinshenger Tuihuang mixture (XTM) and to change the administration route, and to observe its curative effect on neonatal jaundice. Method: Water extraction and alcohol precipitation preparation for improving XTM were used, lotion and enteroclyster were prepared. Patients conforming to inclusion criteria were randomly divided into observation group A, B and control group( n ＝60 each). Control group was given oral dose of phenobarbital sodium 8 mg ·kg^-1,tid. for 4 d; observation group A was given oral dose of XTM 10 mL,tid. for 4 d;and observation group B was given Chinese materia medica as enteroclysm combined with medicated bath bid. for 4 d.Then we detected serum bilirubin(SB)level,compared the effects of jaundice-abating between three groups. Result: Compared with control group, Observation group B was statistical significance( P ＜0.01). Compared with observation group A, the total effective rate in observation group B was raised( P ＜0.05). Conclusion: Chinese materia medica as enteroclysm combined with medicated bath is effective in the treatment of neonatal jaundice. Compared with oral administration it is convenient and deserved to spread in clinic.