雷公藤肝毒性及其作用机制的研究进展

Experimental Progress of Liver Toxicity of Tripterygium wilfordii and Its Mechanism 3*

摘要:

雷公藤系卫矛科雷公藤属木质藤本植物,化学成分复杂,具有多种药理作用,临床应用广泛且疗效显著,但其引起肝毒性的报道也时有发生,因此作者从雷公藤引起肝毒性的物质基础、临床特点、病理学基础以及肝毒性发生的作用机制几个方面进行综述,以便为雷公藤临床安全用药和科学研究提供更多的依据和方法。

Abstract:

Tripterygium wilfordii Hook. f. (TWHF) belongs to Celastraceae. It is a traditional Chinese medicine, with complex chemical constituents and a variety of pharmacological effects. And it is applied for many diseases with significant effects. But the liver toxicity events caused by TWHF were often reported. Liver toxicity caused by TWHF were reviewed in this paper from four aspects including material basis, clinical features, pathological basis and mechanism, in order to provide more reference and methods for clinical safety and scientific research.