三黄散瘀巴布剂的基质配方优选

Optimization of Matrix Formulation of Sanhuang Sanyu Cataplasm

摘要:

目的: 优选三黄散瘀巴布剂的基质配方。 方法: 以巴布剂的外观性状和黏力为评价指标,采用单因素试验和正交试验优选三黄散瘀巴布剂的基质配方。 结果: 三黄散瘀巴布剂的较优基质配方为NP-700-K90-甘油(0.5∶0.4∶6)。取大黄、黄芩合提浓缩液加入卡波姆-u10NF得质量浓度0.02 g·mL^-1溶液,溶胀过夜,作为A相,将聚丙烯酸钠0.5 g和聚乙烯吡咯烷酮0.4 g加入到6 g甘油中作为B相,将三氯化铝和柠檬酸加入到水中作为C相,黄柏单提浓缩液作为D相,将上述4相按A-B-C-D(10∶3∶3∶5)充分混合搅匀,搅拌15 min,涂布,盖上防黏层。 结论: 所优选三黄散瘀巴布剂的基质配方简单、稳定,可推广于大生产应用。

Abstract:

Objective:To optimize matrix formulation of Sanhuang Sanyu cataplasm. Method: Taking appearance and adhesion of cataplasm as evaluation indexes,matrix formulation of Sanhuang Sanyu cataplasm was optimized by single factor test and orthogonal test. Result: Optimized matrix formulation of Sanhuang Sanyu cataplasm was NP-700-K90-glycerol(0.5∶0.4∶6).0.02 g·mL^-1 solution was received by adding carbomer-u10NF into mixed extraction concentrated liquid of Rheum palmatum and Scutellaria baicalensis,swelling overnight, as A phase,0.5 g sodium polyacrylate and 0.4 g PVP were added to 6 g glycerol as B phase,aluminum chloride and citric acid were added to water as C phase,single extraction concentrated liquid of Phellodendron chinense was as D phase,four phases was fully mixed with A-B-C-D(10∶3∶3∶5), stirred 15 min, coating,covered with anti-sticking layer. Conclusion: Optimized matrix formulation of Sanhuang Sanyu cataplasm was simple,stable and feasible,which could be applied to industrial production.