正交试验优化骨炎消巴布剂的基质处方

Optimization of Matrix Prescription for Guyanxiao Cataplasm by Orthogonal Test

摘要:

目的: 优选骨炎消巴布剂的基质配方。 方法: 采用正交设计,选取聚丙烯酸钠(NP-700),羧甲基纤维素钠(CMC-Na),丙三醇和二氧化钛的用量为考察因素,以初黏力、持黏力、综合感官的综合评分为指标,优化骨炎消巴布剂的基质处方。 结果: 优选的基质处方为NP-700 3 g,CMC-Na 0.6 g,丙三醇16 g,二氧化钛0.8 g。 结论: 按优选的基质处方制得的骨炎消巴布剂外观、黏附性良好。

Abstract:

Objective:To optimize matrix prescription of Guyanxiao cataplasm. Method: Matrix prescription was optimized by orthogonal test with initial viscosity,sustained adhesive strength and general sensory as comprehensive evaluation index,the amount of NP700,CMC-Na, glycerol and titania were chosen as factors. Result: Optimal matrix prescription was:NP-700, CMC-Na, glycerol and titania of 3,0.6,16,0.8g,respectively. Conclusion: Guyanxiao catapasm with good appearance and adhesion could be prepared by optimized matrix formulation.