刺五加酸对酒精性肝损伤的影响

The Protective Effect of Acanthoic Acid on Liver Injury in Mice

摘要:

目的: 探讨刺五加酸(AA)对小鼠急性肝损伤的保护作用。 方法: 将60只小鼠随机分成6组,即正常组,乙醇模型组,水飞蓟素组(100 mg·kg^-1),刺五加酸高、中、低剂量组(30,10,5 mg·kg^-1)。小鼠每隔12 h给药1次,连续给药3次。每次给药后1 h,除正常组外均灌胃60%乙醇(5 g·kg^-1)。观察大鼠血清的生化指标和病理组织变化。 结果: 在AA的高、中剂量组ALT(25±6),(31±8)U·L^-1,AST(157±23),(187±18) U·L^-1,TNF-α(32±4.62),(41±5.3) μg·L^-1以及TG(190±23),(257±23) mmol·L^-1明显下降,与模型组比较有显著性差异(P<0.001),减少了肝损伤程度。 结论: 刺五加酸对乙醇引起的小鼠急性肝损伤具有良好的保护作用。

Abstract:

Objective:To study the protective effects of acanthoic acid (AA) against acute liver injury. Method: Sixty mice were andomly divided into six groups: the normal group, the ethanol model group, silymarin group (100 mg·kg^-1), high-dose AA group (30 mg·kg^-1),middle-dose AA group (10 mg·kg^-1) and low-dose AA group (5 mg·kg^-1). Each group received medicine by gavage every 12 hrs for a total of 3 doses.Except for normal group, the other mice were received 60% ethanol (5 g·kg^-1) 1 h. After administrayion. The thehepatic pathological and biochemical index changes in rats were observed. Result: The high-dose AA group and the middle-dose AA group can reduce the level of ALT(25±6),(31±8) U·L^-1, AST(157±23),(187±18) U·L^-1,TNF-α(32±4.62),(41±5.3) μg·L^-1 and TG(190±23),(257±23) mmol·L^-1, which was compared with the model group, and showed a significant difference(P<0.001). Conclusion: The AA could protect mice from ethanol induced acute liver injury efficiently.