清脑降压片治疗高血压(肝阳上亢证)的临床疗效及对血管内皮功能的影响

Clinical Efficacy and Impact of Qingnao Jiangya Tablets on Endothelial Function in Treatment of Liver Yang Hypertension

摘要:

目的: 探讨清脑降压片治疗高血压(肝阳上亢证)的临床疗效及对血管内皮功能的影响。 方法: 156例高血压患 者随机分为治疗组79例和对照组77例。Ⅰ级高血压仅采用清脑降压片治疗,Ⅱ级高血压原有治疗不变加用清脑降压片,对照组采用安慰剂治疗,均口服,4~6片/次,3次/d。疗程4周。观察两组血压、肝阳上亢证,检测一氧化氮(NO)、内皮素(ET-1)。 结果: 清脑降压片能明显降低Ⅰ级、Ⅱ级高血压患者的收缩压(SBP)和舒张压(DBP)(P<0.01);清脑降压片能明显改善患者的肝阳上亢证证候积分,其疾病有效率和证候有效率分别达84.81%,89.87%(P<0.01);清脑降压片能升高NO水平,降低ET-1水平,调节NO/ET-1比值(P<0.01)。 结论: 清脑降压片对Ⅰ,Ⅱ级高血压患者均有明显的降压作用,能改善临床症状,其作用机制可能是通过调节NO/ET-1来实现的。

Abstract:

Objective:To investigate the clinical efficacy and impact of Qingnao Jiangya tablets (QJT) on endothelial function in the treatment of liver yang hypertension. Method: One hundred and fifty-six patients with hypertension were randomly divided into treatment group of 79 cases and control group of 77 cases. Grade Ⅰ hypertension was treated with QJT; Grade Ⅱ hypertension was additionally treated by QJT based on the original treatment, The controls were only received placebo. QJT was orally given 4-6 tablets tid for 4 weeks. Blood pressure, liver yang score, nitric oxide (NO) and endothelin (ET-1) were evaluated for the two groups. Result: QJT significantly reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) for the grade Ⅰ and grade II hypertension patients(P<0.01). QJT significantly improved the patient’s liver yang scores, and the disease efficiency and syndromes efficiencies were 84.81%, 89.87%(P<0.01). QJT increased NO level, reduced ET-1 level and adjusted NO/ET-1 ratio(P<0.01). Conclusion: QJT had obvious antihypertensive effect for grade Ⅰ and grade Ⅱ hypertensive patients. It could improve clinical symptoms, and its mechanism may be achieved by adjusting the ratio of NO/ET-1.