活血补肾中药方联合低剂量美金刚治疗脑卒中后认知功能障碍

Treatment of Cognitive Dysfunction after Stroke by Herbs of Reinforcing the Kidney and Promoting Blood Flow Combined with Small Dose of Memantine

摘要:

目的: 观察活血补肾中药方联合低剂量美金刚治疗脑卒中后认知功能障碍的疗效。 方法: 选取2009年1月至2011年6月我院收治的脑卒中后认知功能障碍患者80例作为观察对象,给予活血补肾中药方联合低剂量美金刚治疗,应用简易智能状态检查量表(MMSE)和蒙特利尔认知评估量表(北京版)(MoCA)分别评估治疗前,治疗后1个月和3个月时的认知功能。 结果: 治疗前患者MMSE评分为(24.84±3.21)分,MoCA评分为(23.76±3.00)分,均低于正常参考值(26分)。随治疗延续,MMSE与MoCA量表评分逐渐增加,治疗1个月时分别为(27.28±4.57和26.47±3.43)分,治疗3个月时分别为(29.78±4.44和28.89±3.37)分,均明显高于治疗前(P<0.05)。随治疗延续,显效率逐渐升高,治疗3个月显效率为21.25%,高于治疗1个月的15.0%(P<0.05);治疗3个月总有效率为86.25%,治疗1个月总有效率83.75%,二者比较无明显差别。 结论: 活血补肾中药方联合低剂量美金刚可改善脑卒中后认知功能,疗效确切,值得推广。

Abstract:

Objective:To observe the effect of herbs of reinforcing the kidney and promoting blood flow combined with low dose of memantine for treatment of cognitive dysfunction after stroke. Method: From January 2009 to June 2011, 80 patients with after stroke cognitive dysfunction were collected as investigative cases. And all patients were given the treatment of herbs of reinforcing the kidney and promoting blood flow combined with small dose of memantine. Then we evaluated the curative effect by applying the simple intelligent state examination scale (MMSE) and Montreal cognitive assessment scale (MoCA, Beijing edition) before treatment, a month and three months after treatment. Result: The MMSE score of all patients was 24.84±3.21 and MoCA score was 23.76±3.00 before treatment, those were all below the normal reference value of 26.Along with the treatment continuance, MMSE and MoCA scores were increased gradually, they were 27.28±4.57 and 26.47±3.43 at one month after treatment, and 29.78±4.44 and 28.89±3.37 at three months after treatment. They were higher than those of before treatment (P<0.05). Along with treatment continuance, significant efficiency gradually raised. The significant efficiency at three months after treatment was 21.25%, which was higher than that at a month after treatment (15.0%) (P<0.05); The total effective rate at three months after treatment was 86.25%, and those at a month after treatment was 83.75%, without significant difference. Conclusion: Treatment by herbs of reinforcing the kidney and promoting blood flow combined with small dose of memantine could improve cognitive function for cognitive dysfunction after stroke. The effect is clear and worthwhile to be applied clinically.