Abstract:Objective:To investigate spray drying process of Coptidis Rhizoma extract. Method: With the amount of spray dry powder,the content of berberine and moisture content as indexes,effect of air inlet temperature,outlet temperature and extract specific gravity on spray drying process of Coptidis Rhizoma extract was investigated by orthogonal test. Result: Optimal spray drying process was:air inlet temperature 180℃,outlet temperature 80℃ and extract specific gravity of 1.15. Conclusion: This optimized process was rational and stable,it could provide experimental basis for industrial production of Coptidis Rhizoma.