膜技术用于川芎茶调颗粒浓缩工艺前后的化学成分动态变化

Dynamic Changes of Chemical Constituents Before and after Concentration Process of Chuanxiong Chatiao Granules by Membrane Technique

摘要:

目的: 研究膜技术应用于川芎茶调颗粒浓缩工艺前后的化学成分动态变化。 方法: 采用单因素试验法优选川芎茶调颗粒膜技术生产工艺参数,结合川芎茶调颗粒的质量标准及HPLC特征图谱,对比采用膜技术和传统浓缩技术生产的川芎茶调颗粒的化学成分变化。 结果: 最佳膜工艺参数为采用SMN-130A 2350054膜,浓缩压力17×10⁴ Pa,浓缩温度36℃;HPLC特征图谱及质量标准对比研究显示2种工艺制备的样品特征峰的个数相同、峰面积无显著性差异,相似度0.97。 结论: 膜技术可用于川芎茶调颗粒的产业化生产。

Abstract:

Objective:To investigate dynamic changes of chemical constituents before and after concentration process of Chuanxiong Chatiao granules by membrane technique. Method: Single-factor test was used to optimize membrane technique industrial production process parameters of Chuanxiong Chatiao granules,by combining with quality standard and HPLC characteristic spectrum of Chuanxiong Chatiao granules,chemical constituents changes of Chuanxiong Chatiao granules with membrane technique and traditional concentration technique were compared. Result: Optimal membrane process parameters were:adopted SMN-130A 2350054 membrane with concentration pressure of 17×10⁴ Pa,concentration temperature of 36℃;Comparative studies of HPLC Characteristic spectrum and quality standards showed that the characteristic peaks’ quantity was equal and peak area was no significant differences of samples,which were prepared by 2 kinds of process,their similarity was 0.97. Conclusion: Membrane technique could be used in industrial production of Chuanxiong Chatiao granules.