冠心康胶囊挥发油β-环糊精包合物的制备工艺优选

Optimization of Preparation Technology of β-Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule

摘要:

目的: 优选β-环糊精包合冠心康胶囊挥发油的制备工艺,提高挥发油的稳定性。 方法: 采用饱和水溶液超声法制备包合物,以挥发油包合率、包合物收得率及包合物含油率为综合评价指标,采用星点设计考察β-CD与挥发油的用量比、包合温度及超声时间等因素对包合工艺的影响,对结果进行多元线性回归和二项式拟合,用效应面法确定最佳工艺条件,并进行预测分析。 结果: 冠心康胶囊挥发油的β-CD最佳包合工艺条件为β-CD与挥发油的用量比7:1,包合温度45℃,超声时间40 min,预测值与理论值偏差<3%。 结论: 通过β-CD包合后可使挥发油粉末化,提高其稳定性。优选的包合工艺方法简便、预测性良好,为冠心康胶囊的工业生产提供试验依据。

Abstract:

Objective:To grope preparation technology of β-cyclodextrin(β-CD) inclusion compound of volatile oil in Guanxinkang capsule,in order to improve stability of volatile oil. Method: Inclusion complexes was prepared by saturated aqueous solution ultrasonic method,with inclusion rate of volatile oil,inclusion oil content and inclusion yield as comprehensive evaluation index,influence of ratio of β-CD and volatile oil,inclusion temperature and ultrasonic time on inclusion technology was investigated by central composite design,test data was fitted by multi-linear regression and binomial equation,inclusion technology conditions were optimized by response surface method,and to predictive analysis. Result: Optimum inclusion process conditions were as follows:ratio of β-CD and volatile oil of 7: 1,inclusion temperature at 45℃ and ultrasonic time of 40 min,deviation between observed and predicted values was less than 3%. Conclusion: Volatile oil was powdered and its stability had been increased after being included by β-CD.This optimized inclusion process was simple with high predictability,it could provide test basis for industrial production of Guanxinkang capsule.