艾可胶囊的澄清工艺优选

Optimization of Clarification Process for Aike Capsule

摘要:

目的: 优选壳聚糖用于澄清艾可胶囊提取液的工艺。 方法: 以芍药苷、柴胡皂苷a的含量和浸膏得率为综合评价指标,选择药液比、壳聚糖加入量、搅拌温度、搅拌时间为考察因素,采用正交试验优选艾可胶囊的澄清工艺。 结果: 艾可胶囊提取液的最佳澄清工艺为药液比1:5,搅拌时间10 min,温度60℃,每100 mL药液加入壳聚糖14 mL。 结论: 优选的工艺芍药苷、柴胡皂苷a的提取率高、稳定性好、成本低,适合于艾可胶囊的临床开发。

Abstract:

Objective:To optimize clarification process for extract of Aike capsule by chitosan. Method: With the content of paeoniflorin,saikosaponin-a and extract yield as comprehensive evaluation index,solid-liquid ratio,the amount of chitosan,stirring temperature and stirring time were selected as factors,orthogonal test was carried out to optimize clarification process of Aike capsule. Result: Optimum clarification process of Aike capsule extract was:solid-liquid ratio 1: 5,stirring time 10 min at 60℃,added chitosan 14 mL per 100 mL extraction solution. Conclusion: This optimized process had advantages of good stability,low cost and high extraction rate of paeoniflorin and saikosaponin-a,it was suitable for clinical development of Aike capsule.