紫丁香叶的化学成分研究

Chemical Constituents of Syringa oblata Leaves

摘要:

目的: 对木犀科丁香属植物紫丁香叶的化学成分进行研究。 方法: 采用硅胶柱色谱法、重结晶及制备高效液相色谱等技术提取分离,利用紫外(UV)、红外(IR)、质谱(EI-MS)、核磁共振(¹H-NMR,¹³C-NMR)、异核多量子关系谱(HMQC)及多键碳氢关系谱(HMBC)等光谱方法鉴定化合物结构。 结果: 分析并鉴定了9个化合物的结构:(+)松脂素-4″-O-β-D-葡萄吡喃糖苷(1),(+)表松脂素-4-O-β-D-葡萄糖苷(2),落叶松脂醇-4-O-β-D-葡萄吡喃糖苷(3),3,4:3',4'-bis(methylene-dioxy)-9'-hydroxyl-lignane-9-methyl-O-β-D-葡萄吡喃糖苷(4),2-(3,4-dihydroxyphenyl)ethyl(1R,4aS,8R,8aS)-8-methyl-6-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy)oxan-2-yl]oxy-4a,5,8,8a-tetrahydro-1H-pyrano[3,4-c]pyran-4-carboxylate(5),3,4-二羟基苯乙二醇(6),对羟基苯乙醇(7),6-O-(E)-feruloyl-(α)-glucopyranoside(8),6-O-(E)-feruloyl-(β)-glucopyranoside(9)。 结论: 化合物 1~6 为首次从该植物分离得到的化合物。

Abstract:

Objective:To investigate the chemical compositions of the leaves of Syringa oblata. Method: The separation was performed by using silica gel column chromatography, recrystallization and the HPLC preparation methods. The compound structures were identified according to the spectral analytical methods UV, IR,¹H-NMR,¹³C-NMR, HSQC and HMBC. Result: The structures of the nine compounds were fully determined by the chemical and physicochemical evidences. They were (+)pinoresinol-4″-O-β-D-glucopyranoside(1). lariciresinol-4-O-β-D-glucopyranoside (2). (+)epipinoresinol-4-O-β-D-glucopyranoside (3). 3,4: 3',4'-bis(methylene-dioxy)-9'-hydroxyl-lignane-9-methyl-O-β-D-glucopyranoside (4). 2-(3,4-dihydroxyphenyl) ethyl (1R,4aS,8R,8aS)-8-methyl-6-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy)oxan-2-yl]oxy-4a,5,8,8a-tetrahydro-1H-pyrano[3, 4-c]pyran-4-carboxylate(5). 3,4-dihydroxybenzene-Styrene glycol (6). 4-hydroxyphenethyl alcohol (7). 6-O-(E)-feruloyl-(α)-glucopyr-anoside (8). 6-O-(E)-feruloyl-(β)-glucopyranoside (9). Conclusion: All of the constituents are obtained in leaves of S. oblata; among them, compounds 1-6 are reported in this species for the first time.