南寒水石炮制工艺及药效学初探

Processing Technology and Pharmacodynamics of Hanshuishi

摘要:

目的: 优选南寒水石的炮制工艺,并对其药效进行初步研究。 方法: 通过四因素三水平的正交试验,以煅后性状和CaCO₃含量作为观测指标对炮制方法进行评估。动物分为模型组、100 mg·kg^-1雷尼替丁组、360.4 mg·kg^-1洁白丸成药组、334.3 mg·kg^-1去寒水石洁白丸组、26.1 mg·kg^-1河南产、浙江产和新疆产南寒水石组,分别灌胃给予相应药物连续7 d后,幽门结扎法建立大鼠胃液分泌增加模型,观察寒水石对大鼠胃液分泌量、pH值和胃液酸度的影响。 结果: 南寒水石炮制后性状以质酥,色白,触及为细粉状为指标,其最佳工艺条件为粉碎粒度为粉末(过20目),温度为1 000℃,时间为1.5 h;除浙江产南寒水石对胃液排出量无影响外,南寒水石各组和去寒水石洁白丸组均能显著引起幽门结扎大鼠胃液分泌量减少,pH增加,胃液总酸度和1 h酸排出量下降;洁白丸组除可增加pH以外对其他指标无影响,河南产南寒水石药效最优,浙江产南寒水石表现欠佳。 结论: 南寒水石对大鼠胃液分泌有抑制作用,且不同产地南寒水石药效有所不同。

Abstract:

Objective:To optimize the processing technology of Hanshuishi and obtain the basic pharmacodynamic parameters. Method: An orthogonal experiment of four factors and three levels was conducted to evaluate the Hanshuishi processing technology, and the characters of calcined products and CaCO₃ content were used as observation indexes. The animals were divided into model group, 100 mg·kg^-1 Ranitidine group, 360.4 mg·kg^-1Jiebai Wan group, 334.3 mg·kg^-1the Jiebai Wan removed Hanshuishi group, 26.1 mg·kg^-1 henan Hanshuishi, zejiang Hanshuishi and xinjiang Hanshuishi groups, Pylorus-ligated rat model was applied to observe the effect on gastric juice volume, acidity and pH value of the rats subjected to intragastric administration. Result: The processed traits of Hanshuishi were crisp, white color and powder. The optimum conditions of the Hanshuishi were particle size of powder (20 mesh), temperature of 1 000℃, time 1.5 h; In addition to the 13th sample produced in Zhejiang, the other Hanshuishi groups and the Jiebai Wan group removed Hanshuishi could significantly decrease the volume, total acidity and 1 h acid excretion of gastric juice of experimental rats and increase pH value; Except of increasing the pH value, Jiebai Wan group had no effect, The efficacy of henan Hanshuishi was optimal and the Zejiang one had a poor performance. Conclusion: Hanshuishi inhibited gastric secretion of rats; moreover, the efficacy of Hanshuishi from different areas has slightly different.