黄连解毒汤治疗重症肛周脓肿

Huanglian Jiedu Decoction in Treatment of Perianal Abscess of Severe Type

摘要:

目的: 研究黄连解毒汤治疗重症肛周脓肿的疗效及作用机制。 方法: 将重症肛周脓肿住院手术患者随机分为两组,治疗组(n=30)术后常规治疗的基础上口服黄连解毒汤,对照组(n=26)术后常规治疗。观察术后两组患者体温(T)、切口红肿情况,检测术前及术后第3天血白细胞(WBC)、血清内毒素(ET)、肿瘤坏死因子α(TNF-α)水平。 结果: 术前两组各检测指标均无明显差异,术后第3天治疗组WBC,T低于对照组,但无统计学差异,切口红肿程度,血清ET,TNF-α水平显著低于对照组(P<0.01)。 结论: 术后口服黄连解毒汤是治疗重症肛周脓肿的有效方法,其可能通过降低血清ET水平,下调TNF-α来发挥治疗作用。

Abstract:

Objective:To investigate the therapeutic efficacy and mechanism of Huanglian Jiedu decoction in treatment of perianal abscess of severe type. Method: Patients with perianal abscess of severe type received operation in hospital were divided into two groups randomly, treatment group (n=30) took Huanglian Jiedu decoction orally on the basis of routine therapy after operation, control group (n=26) only received routine therapy. The body temperature, red and swollen around cut were observed. The level of white blood cell (WBC), serum endotoxin(ET), tumour necrosis factor α (TNF-α) of two groups before treatment and on the third day after treatment were tested. Result: There were no significant differences in all data before treatment between two groups. The body temperature and the number of WBC in treatment group was lower than those in control group on the third day, but there was no statistical difference. The degree of red and swollen around cut, serum ET, TNF-α on the third day after treatment in treatment group were lower than those in control group (P<0.01). Conclusion: Huanglian Jiedu decoction is an effective method in treatment of perianal abscess of severe type, which plays a therapeutic action through reducing serum endotoxin and down regulating the level of TNF-α.