治疗小儿手足口病遣药组方关联规则探讨

Study on Formula Rules of Chinese Herbal Compound in Treatment of Hand Foot and Mouth Disease in Children

摘要:

目的: 应用数据挖掘方法中关联规则探讨小儿手足口病用药规律。 方法: 收集2000年1月至2010年12月收载的公开发表的期刊杂志,选取临床报道治疗无不良反应,治疗例数在20人以上的中药复方126首,以Excel 2003软件建立数据库,收录每首中药复方的单味药药名并进行统计分析,对使用频率较高的药物进行关联规则的挖掘和分析。 结果: 在126首中药复方中共使用了156种药物频次为1 625次。其中,使用频次在10次以上的依次为金银花、甘草、连翘等40味中药。在关联规则集中,由2味药、3味药、4味药及5,6味药组成的强关联规则分别有8,6,7,7条。 结论: 药物的配伍主要验证了热邪、风邪及湿邪3个因素与手足口病的关系。

Abstract:

Objective:To discuss the firmula regularity of Chinese herbal compound in the treatment of hand-feet-mouth disease in children. Method: The data was collected from January, 2000 to December, 2010.More than 126 Chinese herbal formulas used in 20 cases and without adverse reaction, were searched through the CNKI medical database; and the database was set up using Excel 2003 software, the name of each herbal medicine in the compound was collected for a statistical analysis. The herbs which were frequently used were analyzed to obtain formula rules. Result: Of the total 126 Chinese herbal compound in the treatment of hand-feet-mouth disease in Children, for 156 kind of hebs the frequence of application reached 1 625, and the top 10 in application were honeysuckle, glycyrrhiza and weeping forsythia,etc. Conclusion: The relationship between the three factors(heat evil, pathogenic wind, and pathogenic dampness) and hand foot and mouth disease was verified through the study of the Chinese herbal compound in the treatment of hand-feet-mouth disease in Children.