分子配伍理论科学内涵及在现代中药研发中的应用

Scientific Connotation of Molecule Compatibility and Role in Research and Development of Modern Chinese Medicine

摘要:

提出分子配伍理论,为现代中药研究提供理论指导。阐述分子配伍理论产生的背景、必然性和科学内涵,及分子配伍理论的特征。论述分子配伍理论指导下的现代中药(成分中药)的特征。结果显示分子配伍理论具有3个特征:①分子配伍理论体现了中西医的有机结合;②分子配伍理论系统思维与分析还原法的有机结合;③坚持中医药理论的整体观。现代中药具有5个特征:①方中所有成分化学结构、分子式、分子量均清楚;②分子配伍符合方剂学君臣佐使的原则;③作用机制清楚、疗效确切、剂型先进、质量稳定可控;④多通道、多途径、多层次、多靶点对患病机体产生网络药理作用;⑤对复杂性、系统性疾病疗效明显,副作用小。中药现代化的关键是中医药理论现代化。分子配伍理论的提出,是时代发展的必然产物,必将促进中医药事业的繁荣昌盛。

Abstract:

Molecular Compatibility theory was put forward to provide theoretical guidance for modern Chinese medicine(molecular Chinese medicine).They were expounded to the background, scientific connotation, necessity,features of Molecular Compatibility theory and characteristics of modern Chinese medicine. Molecular compatibility theory had three features.①It reflected the concept of organic combination of Chinese and western medicine.②Systematic thinking combined with analysis reduction method organically.③The overall concept of TCM theory was adhered to;Characteristics of modern Chinese medicine by molecular compatibility theory was three.①They were clear of the chemical structure, molecular formula, molecular weight of all ingredients in prescription. ②The principle of dunchenzuoshi was followed. ③It had clear mechanism, definite effect, advanced dosage forms, stable quality control. ④ Multichannel, multi-evel and multi-channel network pharmacological effects were produced in sick body.⑤Efficacy was obvious and side effects were small for complexity, systemic diseases.The key to modernization of TCM was the modernization of TCM theory.Molecular compatibility theory, was the inevitable outcome of the development of The Times, which would promote the prosperity of Chinese medicine.