超微粉碎对七厘散稳定性的影响

Influence of Ultrafine Grinding on Stability of Qili Powders

摘要:

目的: 研究超微粉碎对七厘散稳定性的影响。 方法: 将七厘散细粉及微粉分别置于高湿、高温及光照环境中,定期考察2种粉体的含水量、休止角、血竭素含量及体外溶出度。 结果: 七厘散细粉及微粉在高湿环境下含水量均升高,流动性和血竭素含量下降,血竭素溶出无显著变化;在高温环境下2种粉体的含水量均下降,流动性增加,血竭素溶出均降低,细粉中血竭素含量下降,微粉中则无显著变化;光照条件下2种粉体含水量均升高,流动性无显著变化,血竭素含量均下降,细粉中血竭素溶出下降,微粉中则无显著变化。 结论: 微粉在高温环境下血竭素体外溶出稳定性较细粉差,光照条件下微粉较细粉稳定性高,其余条件下二者各指标的变化均不明显。

Abstract:

Objective: To investigate influence of ultrafine grinding on stability of Qili powders. Method: Common powder and micropowder of Qili powders were placed in the high humidity,high temperature and lighting conditions separately,the moisture content,angle of repose,content of dracorhodin and in vitro dissolution were measured regularly. Result: Under the high humidity cindition,the moisture content of these two kinds of powders increaced,while the flowability and the content of dracorhodin droped significantly,dissolution of dracorhodin had no significant change.Under the high temperature condition,the moisture content of the common powder and the micropowder droped,the flowability increased while dissolution behavior of dracorhodin became bad,the content of dracorhodin in the common powder droped while there was no significant change in the micropowder.Under the lighting condition,the moisture content of these two kinds of powders increaced,while the flowability remained and the content of dracorhodin droped significantly,dissolution behavior of dracorhodin in the common powder became bad,but it kept stable in the micropowder. Conclusion: Compared with the common powder,in vitro dissolution stability of dracorhodin in the micropowder was worse under the high temperature,but the micropowder was more stable under the lighting condition.Change of each assessment index had no significant difference between the common powder and the micropowder under the remaining conditions.