鸦胆子油自微乳的制备及溶出度考察

Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion

摘要:

目的: 制备鸦胆子油自微乳,并考察其溶出度。 方法: 通过溶解度试验、气相色谱法筛选辅料,伪三元相图优化自微乳处方,并进行药物溶出度试验。 结果: 鸦胆子油自微乳最优处方为鸦胆子油-辛酸癸酸三甘油酯-聚氧乙烯氢化蓖麻油-聚乙二醇400 12:12:65:11,乳滴粒径<50 nm,15~20 min可基本完全溶出。 结论: 鸦胆子油自微乳稳定性良好,提高了用药的顺应性,且制备工艺简单。

Abstract:

Objective: To prepare Brucea javanica oil self-microemulsion,and investigate its dissolution. Method: Solubility test and gas chromatography were used to select adjuvants,pseudo-ternary phase diagram was used to optmize prescription of the self-microemulsion,and dissolution test of the self-microemulsion was adopted. Result: Optimum prescription of B. javanica oil self-microemulsion was B. javanica oil-caprylic capric triglyceride-polyoxyethylene hydrogenated castor oil-polyethylene glycol 400 12%: 12%: 65%: 11%,particle size of it was<50 nm and it could be completely dissolved in 15-20 minutes. Conclusion: B. javanica oil self-microemulsion had good stability,it improved medication compliance,and this preparation technology was simple and stable.