马山地不容的生物碱成分

Akaloids Roots of Stephania mashanica

摘要:

目的: 研究马山地不容Stephania mashanica的化学成分,为其资源开发提供化学成分资料。 方法: 应用氧化铝、硅胶和葡聚糖凝胶LH-20等柱色谱方法分离化合物,根据理化性质测试和波谱分析鉴定化合物结构。 结果: 从马山地不容新鲜块茎的稀硫酸提取物中,分离得到7个生物碱成分:荷包牡丹碱(dicentrine, 1)、克班宁 2]、青风藤碱(sinoacutine, 3)、四氢非洲防己胺(tetrahydrocolumbamine, 4)、四氢巴马汀(tetrahydropalmatine, 5)、巴马汀(palmatine, 6),药根碱(jatrorrhizine, 7)。 结论: 化合物 2~7 为首次从马山地不容中分离得到。

Abstract:

To provide the chemical data for resources development of Stephania mashanica,its chemical constituents were investigated; Method: The powered tuber of S. mashanica were extracted with 2% H₂SO₄-H₂O and purified by silica gel, alumina oxide and Sephadex LH-20 column chromatograph. The structures were elucidated on the basis of spectral analysis and physico-chemical evidence. Result: Seven alkaloids were isolated from the thin sulfuric acid extracts of the fresh roots of Stephania mashanica, these alkaloids were identified as dicentrine (1), (() -crebanine (2), sinoacutine (3), tetrahydrocolumbamine (4), tetrahydropalmatine (5), palmatine (6), and jatrorrhizine (7). Conclusion: compounds 2-7 were obtained from this plant for the first time.