Abstract:Objective: Compare the proposed traditional prescription joint metalizing and mesalazine treatment the curative effect of ulcerative colitis, provide rational drug use advice for clinical treatment of ulcerative colitis. Method: Ninty cases of ulcerative colitis patients in our hospital from June 2010 to May 2011, randomly divided into treatment group (45 cases) and control group (45 cases), were given the proposed traditional prescription joint mesalazine and mesalazine treatment respectively. After that, compare with two groups of treatment effective rate, under colonoscopy form change,C-reactive protein(CRP),ergthrocyte sedimentration rate(ESR) etc, evaluate its effectiveness and safety. Result: The treatment effective rate and under colonoscopy form change of the two groups after treatment are all have statistical significance (P<0.05). Conclusion: The curative effect of the proposed traditional prescription joint mesalazine is better than that of mesalazine. It is worthy of clinical application.