不同来源沉香药材中重金属含量及其安全性分析

Determination of Heavy Metal in Agarwood from Different Resources and Evaluation on its Safety

摘要:

目的: 测定15份不同来源沉香药材中铜、铅、砷、汞、镉、铬、锰、钴、镍、锌、锡、钡、钛、硒等14种重金属元素含量,并对其安全性进行分析。方法: 沉香药材粉末经微波消解后,用电感耦合等离子质谱法测定各样品中上述14种重金属元素的含量。结果: 7份市售沉香样品中有4份样品中铅元素或镉元素超过国家药典委员会规定的最低限量要求。7份通体结香沉香和1份接菌法沉香样品中5种有害重金属元素含量都满足国家药典委员会规定的限量标准要求。结论: 目前沉香药材市场鱼龙混杂,有害重金属含量超标现象严重,其用药安全性堪忧。

Abstract:

Objective: To determine the content of Cu, Pb, As, Hg, Cd, Cr, Mn, Co, Ni, Zn, Sn, Ba, Ti and Se in fifteen agarwood from different resources and evaluate their safety. Method: The samples were digested by microwave digestion method, and detected by inductively coupled plasma mass spectrometry method. Result: The content of Pb and Cd of four samples from seven merchant samples were overrun the limit by China Pharmacopoeia Committee. However, the content of Cu, Pb, As, Hg and Cd of the other eight samples, including seven agarwood samples produced by whole-tree agarwood-inducing technique and one agarwood sample produced by fungi-inoculation method, met the requirement of Chinese Pharmacopoeia. Conclusion: At present now, the content of harmful heavy metal from lots of merchant agarwood were overrun the limit. It has become a very serious phenomenon. Therefore, we must pay high attention to the safety of agarwood for medicine.