乳膏液晶胶网微观结构形成理论与表征的研究进展

Research Progress on Cream with Liquid Crystalline Gel Network Microstructure Formation Theory and Characterization

摘要:

对乳膏液晶胶网结构的形成理论、组成要素、稳定机制及微观结构的表征进行介绍,为乳膏液晶胶网微观结构形成理论与表征的研究提供参考。检索近年来国外内乳膏液晶胶网微观结构的相关文献,结果显示此类结构的乳膏由表面活性剂、两亲性化合物和水形成,其结构分为亲水凝胶相、亲脂凝胶相、自由水相和分散相,通过偏振光显微镜和冷冻-透射电镜清晰地观察到其内部微观结构。液晶胶网理论能诠释乳膏的内部构造,从而能进一步解释乳膏稳定性机制。这种具有液晶胶网结构的乳膏运用显微技术将其表征出来,更加直观形象地观察到其内部微观结构,为以后研究这类液晶胶网结构提供了一定的参考。有序排列的液晶胶网结构比普通乳膏制剂有更好的稳定性、缓释性与保湿性等优良的物理化学性能,对于优化生产、药物活性成分的传递与释放、皮肤水合作用及其通透性,具有十分重要的意义。

Abstract:

This paper focuses on a cream with liquid crystalline gel network structure formation theory, elements stabilizing mechanism and microstructure characterization reviewed. Cream mainly composed of the surfactant, an amphiphilic compound and water is formed, creams with liquid crystalline gel network structures are supposed to be four-phase systems,including the hydrophilic gel phase, the lipophilic gel phase, bulk water phase and dispersed phase,through a polarized light microscopy and cryo-transmission electron microscope (Cryo-TEN) can be clearly observed to its internal structure.