人参皂苷Rg1透皮吸收研究进展

Literature Review of Transdermal Absorption in Ginsenoside Rg1 from Notoginseng Radix et Rhizoma

摘要:

基于人参皂苷Rg₁药理作用的不断发现和中药透皮制剂的不断发展,对人参皂苷Rg₁透皮吸收研究进行整理。文章查阅了近几年来的国内外相关资料,从透皮给药的选择、影响透皮吸收的因素以及透皮吸收促进剂等方面对人参皂苷Rg₁的透皮吸收研究状况进行整理分析。结果显示人参皂苷Rg₁具有一定的透皮性能;影响其透皮吸收的因素繁多,而剂型与基质的选择为决定性因素;开发和选择不同化学、中药以及复合促透剂来改善其透皮性能具有重要研究意义。人参皂苷Rg₁透皮吸收的研究能为其新型透皮制剂的开发和临床合理应用提供理论依据。

Abstract:

As the ever-accelerated discovering of ginsenoside Rg₁' s pharmacological activities and updating of traditional chinese medicine percutaneous preparation, recent relevant references and information were summarized, and further analyzed and reviewed in this paper. Research conditions of transdermal absorption in ginsenoside Rg₁ was summarized briefly, which generally included choices of cutaneous penetration, influence factors of transdermal absorption and penetration enhancers. The results showed that ginsenoside Rg₁ has a certain transdermal performance.Factors affecting its transdermal are numerous, which the matrix is selected as the decisive factor. Development and selection of different chemical, medicine and composite penetration enhancers to improve ginsenoside Rg₁'s transdermal performance are significant.Transdermal absorption of ginsenoside Rg₁ will provided reasonable theoretical basis for its new transdermal preparations and clinical application.