淫羊藿苷的稳定性及其影响因素

Stability of Icariside and Factors Affecting the Stability

摘要:

目的：分析测定淫羊藿苷在不同条件下的稳定性及其影响因素。方法：采用紫外-可见分光光度法在200~600 nm扫描，测定不同条件下对淫羊藿苷结构的影响。结果：在微酸性、微碱性和中性条件下，淫羊藿苷可保持结构稳定。在pH<2和pH>10 时，结构发生明显变化；淫羊藿苷热稳定性较好，在100 ℃长时间加热其仍可以稳定存在；能与过渡金属离子Cu²⁺，Fe³⁺，Al³⁺形成络合物，对淫羊藿苷的氧化起到了诱导催化作用从而对其结构有明显的影响。结论：紫外-可见光谱法能够初步考察不同条件下对淫羊藿苷稳定性的影响，为淫羊藿苷的提取、制剂和衍生物制备等提供重要信息。

Abstract:

Objective: To analyze and determine the stability of icariside and its factors affecting in different conditions. Method: On the basis of ultraviolet-visible spectrum under 200-600 nm region scan, determine the factors affecting the chemical structure of icariside in different conditions. Result: Icariside was stable in water, incruding slightly acidic, basic and neutral conditions.When it existed in aqueous phase under pH<2 or pH>10 conditions, the chemical structure of icariside was changed. Furthermore, its aqueous phase under 100 ℃ for a long time was remain stable. In the processes of extracting and using icariside, metal ion such as Cu²⁺, Fe³⁺and Al³⁺ should be wiped off, as they were able to chelate with icariside, and could induce oxidation as well. Conclusion: Using ultraviolet-visible spectrum can primary observation the factors affecting the stability of icariside in different conditions, and providing important information on its extraction, preparation and derivatives preparation.