冰片对神经递质影响相关基础研究的系统评价

Influence of Borneol on Neurotransmitters：a Systematic Review of Relevant Basic Research

摘要:

目的：系统评价冰片对神经递质影响相关基础研究概况。方法：计算机检索PubMed（1996~2012）、VIP（1989~2012）、万方数据库（1990~2012）、CNKI（1979~2012），收集冰片对神经递质影响相关的基础研究。按纳入排除标准筛选研究、由2名研究者根据事先设计好的信息提取表提取相关文献信息，并对纳入研究质量进行评价。结果：共纳入11个基础研究，显示冰片对中枢单胺类、氨基酸类、β-内啡肽及周围儿茶酚氨类神经递质均有一定影响（P<0.05），并与给药剂量、造模方法、取材部位、时间有关。乙酰胆碱组和对照组相比，两者相比差异无统计学意义。结论：由于纳入试验研究方法、模型、给药均存在差异，结果并不统一，相互之间难以印证，在方法学及研究体系方面尚需进一步加强。

Abstract:

Objective: To systematic review the basic research's about the effect of borneol on neurotransmitters. Method: We searched Pub Med (1996 to 2012), VIP (1989 to 2012), Wan Fang Database (1990 to 2012), CNKI (1979 to 2012), and collected basic research literature related to borneol's impacts on neurotransmitter. The publications were screened, assessed and extracted valid data based on predetermined criteria. Result: A total of 11 basic researches were identified,found that borneol have a certain influence on content of monoamine, amino acids, beta-endorphin in central nervous system and catecholamine peripheral, and the outcome was related to the dose, the modeling methods, drawn parts, drawn time. One study showed that the central acetylcholine content have no difference between the experimental group and the control. Conclusion: Because of the researches obtain different methods, models, administration, the results are not uniform, difficult to prove each other, and the methodology and research system needs to be further strengthened.