四逆汤化学物质基础及配伍机制的研究进展

Progress on Chemical Basis and Compatible Mechanism of Sini Decoction

摘要:

通过对近年来国内外四逆汤研究的文献回顾，针对四逆汤组方药物的化学成分，整理了其与强心、抗心律失常等药理作用的关系，并从吸收与代谢角度阐明复方的配伍机制，揭示了四逆汤配伍的合理性和科学内涵。四逆汤是一首组方简单、疗效确切的经典方，临床应用十分广泛。目前国内外对四逆汤的主要研究方向多集中在3味药中主要活性成分对心血管系统的作用，但对于复方的药效物质基础及从药物吸收、代谢层面阐释配伍机制的系统研究则较为有限。建议将四逆汤复方药物的有效组分与药理作用结合进行综合分析（PK/PD联接），借鉴现代先进分析技术（如HPLC、LC-MS/MS等），寻找复方体内药效物质基础，诠释减毒增效机制，解析复方配伍规律的科学性，对临床上安全、有效用药和四逆汤方剂的二次开发具有重要的意义。

Abstract:

Literatures of Sini decoction in recent years were reviewed. In this paper, the studies on cardiotonic, antiarrhythmic effects of chemical components of Sini decoction are summarized. To illustrate the compatible mechanism of Sini decoction based on absorption and metabolism.The aim of this study is to reveal the rational and scientific connotations of compatibility of Sini decoction. Sini decoction is a simple Chinese classic herbal formula. There are various studies that reported the major active ingredients in these three herbs (Radix Aconiti Laterlis, Zingiber officinale Rosc and Radix Glycyrrhizae) has been widely used to treat cardiovascular diseases in clinics at home and abroad. So far, there is limited systemic research on chemical substances and compatible mechanism focused on absorption and metabolism of Sini decoction. Therefore, pharmacokinetics-pharmacodynamics (PK-PD) correlation, advanced analysis techniques (such as high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)) should have been carried out in order to seek the chemical basis in vivo, interpret the decreasing toxicity and increasing efficacy compatible mechanism, and to provide useful information for safe, effective use and re-evaluation of Sini decoction.