五灵脂低温超微粉碎特性考察

Investigation of Cryogenic Pulverization Properties of Faeces Trogopterori

摘要:

目的：研究五灵脂的粉体学性质，探讨其粉体学性质与体外溶出行为的相关性。方法：采用振动式低温超微粉碎机对五灵脂进行粉碎，每3 min取样，检测样品粒径、比表面积、孔隙率；以总黄酮含量为指标，考察五灵脂粉体的体外溶出速率，并分析其粉体学性质与体外溶出行为的相关性。结果：随着粉碎时间的增加，粒径逐渐减小，比表面积及体外溶出速率逐渐增加；粉末粒径与体外溶出速率具有良好相关性。五灵脂粉碎时间选择21 min，粒径以d_0.9约100 μm为宜。结论：五灵脂低温超微粉碎后粒子形态及结构均匀，溶出速率快，有助于后续制剂工艺及质量控制的评价。

Abstract:

Objective: To study powder properties of Faeces Trogopterori and investigate relativity between powder properties and in vitro dissolution behavior. Method: Faeces Trogopterori was crushed by vibration type low temperature ultrafine pulverizer, sampling every 3 min, particle size, specific surface area and porosity of samples were detected;With the content of total flavonoids as index, in vitro dissolution rate of Faeces Trogopterori powder was investigated, relativity between powder properties and in vitro dissolution behavior was analyzed. Result: With increasing grinding time, particle size decreased, specific surface area and in vitrodissolution rate increased;Powder size and in vitro dissolution rate had a good correlation.Grinding time of Faeces Trogopterori selected 21 min, but particle size of d_0.9 should choose was about 100 μm. Conclusion: After low-temperature ultrafine ground of Faeces Trogopterori, particle morphology and structurewas uniform with high dissolution rate, which was helpful forits subsequent evaluation of preparation process and quality control.