正交试验优选无名异的炮制工艺

Optimization of Processing Technology of Pyrolusitum by Orthogonal Design

摘要:

目的：优选无名异的炮制工艺。方法：以MnO₂含量为指标，通过正交试验考察煅制温度、米醋用量、煅制时间对无名异炮制工艺的影响，考察炮制工艺对MnO₂含量及药材显微形态的影响。结果：最佳炮制工艺为煅制温度700 ℃，米醋用量20%，煅制时间40 min；生品和炮制品中MnO₂质量分数（x±s，n=3）分别为（6.13±0.50）%，（7.35±3.27）%；与生品相比，无名异经煅制醋淬后，在光学显微镜下观察到透明晶体的数量增加，在偏光显微镜下观察到有色晶体的数量增加，晶体的外型均呈块状或肾状。结论：优选的无名异炮制工艺稳定可行，为无名异的炮制工艺规范提供参考。

Abstract:

Objective: To optimize processing technology of pyrolusitum. Method: Taking the content of MnO₂ as index, orthogonal test was designed to optimize processing technology of pyrolusitum with processing temperature, the amount of vinegar and processing time as factors.Effects of processing technology on the content of MnO₂ and microscopic morphology of pyrolusitum before and after processed were investigated. Result: The best processing technology of pyrolusitum were identified as calcining for forty min under temperature of 700 ℃ with vinegar amount of 20%;Under these conditions, the mass fraction of MnO₂ in crude and processed products were (6.13±0.50)% and (7.35±3.27)%, respectively;Compared with crude products, after vinegar quenched of pyrolusitum, its transparent crystals number increased which could be observed under an optical microscope, appearance of crytals showed a lump or kidney shaped. Conclusion: This optimized technology was stable and feasible, which could provide a reference for criterion of processing technology of pyrolusitum.