宣白承气汤治疗误吸综合征

Clinical Study of Xuanbai Chengqi Tang Therapeutic Aspiration Syndrome

摘要:

目的：评价宣白承气汤治疗误吸综合征的临床疗效。方法：采用随机、对照研究方法，设置宣白承气汤组和对照组，两组患者组内又分为机械通气组（MV）和非机械通气（NO-MV）两个亚组。对照组，采用西医常规治疗手段；宣白承气汤组，在西医常规治疗基础上，加用宣白承气汤口服。①观察记录内容包括：治疗前及治疗5 d后氧合指数（PaO₂/FiO₂）、体温、白细胞计数、C反应蛋白（CRP）等。②疗效评价：对患者2周后的肺部情况进行评价。结果：① 经5 d治疗后，宣白承气汤组与对照组进行亚组之间比较，无论是MV或是NO-MV两亚组间氧合指数、体温差异有统计学意义（P<0.05）、而体温、白细胞计数方面，两组仅在NO-MV亚组有统计学差异（P<0.05）。②治疗2周后，评价两组患者肺损伤的预后，二者疗效差异有统计学意义（P<0.05）。结论：西医常规治疗基础上配合宣白承气汤有助于减轻患者的肺部损伤，提高治疗效果，其机制可能与减轻全身炎症反应有关。

Abstract:

Objective: To evaluate the clinical effect of Xuanbai Chengqi tang therapeutic aspiration syndrome. Method: A randomized, controlled study methods, seting Xuanbai Chengqi tang group and the control group. Each group is divided into two subgroups of patients group mechanical ventilation (MV) and non-mechanical ventilation (NO-MV). Control group, the use of conventional Western medicine treatment;Xuanbai Chengqi tang group, on the basis of conventional Western medicine, Plus Xuanbai Chengqi tang orally. ① Observations content include:before treatment and after 5 days oxygenation index (PaO₂/FiO₂), body temperature, white blood cell count, C-reactive protein (CRP) and so on. ② Therapeutic evaluation:after 2 weeks of treatment, patients were evaluated prognosis of lung injury. Result: ① After 5 days treatment, Xuanbai Chengqi tang group comparison control group between subgroups, Whether NO-MV or MV two subgroups oxygenation index, temperature difference was statistically significant (P<0.05) and but body temperature, white blood cell count, the two groups only in the NO-MV subgroups were significantly different (P<0.05). ② After 2 weeks of treatment, two groups patients were evaluated prognosis of lung injury, there are statistically significant difference in clinical effect (P<0.05). Conclusion: Based on the conventional Western medicine treatment, with the Prescription of Xuanbai Chengqi tang helps reduce the patient's lung damage, improve the therapeutic effect, its mechanism may reduce the systemic inflammatory response.