祛风润肺通络止咳方辨证治疗慢性咳嗽45例

Qufeng Runfei Tongluo Zhike Decoction Differentiation Treatment on Chronic Cough with 45 Cases

摘要:

目的：探讨祛风润肺通络止咳方治疗慢性咳嗽的临床疗效及对患者生活质量的影响。方法：将90例慢性咳嗽患者随机按就诊顺序分为对照组和观察组各45例。两组均参照“咳嗽的诊断与治疗指南”针对不同病因给予相应治疗。对照组采用百合固定金丸，6 g/次，3次/d。观察组采用祛风润肺通络止咳方，1剂/d，常规水煎分2次服用。两组疗程均为2周。记录日间/夜间咳嗽症状积分、记录咳痰等兼证积分、记录咳嗽消失时间及治疗后咳嗽消失率，采用莱切斯特咳嗽问卷（LCQ）评价患者生活质量。结果：观察组总有效率为90.6%优于对照组的80.0%（P<0.05）；治疗后观察组日间和夜间咳嗽积分均低于对照组（P<0.01）；治疗后观察组咳嗽等兼证积分及症状总积分均低于对照组（P<0.01）；观察组咳嗽消失时间（7.73±1.82）d少于对照组的（9.85±1.76） d（P<0.01）；观察组咳嗽消失率44.44%优于对照组的22.22%（P<0.05）；治疗后观察组LCQ量表之生理状况、心理健康、社会功能3个维度及总分均高于对照组（P<0.01）。结论：祛风润肺通络止咳方能减轻慢性咳嗽患者咳嗽等主要症状，改善患者生活质量，临床疗效显著。

Abstract:

Objective: The purpose is to discuss the clinical effects of Qufeng Runfei Tongluo Zhike decoction differentiation treatment on chronic cough and the influence of the decoction on patients'life quality. Method: Ninety cases of patients with chronic cough were randomly divided into control group (45 cases) and observation group (45 cases)according to the sequence of being in hospital.Both groups aimed at different pathogeny using corresponding treatment referred to'cough diagnosis and treatment guide'.For patients in control group, they took Baihe Guidingjin, 6 g/time, 3 times/day. Patients in observation group took Qufeng Runfei Tongluo Zhike decoction, 1 does/day, conventional water frying and taken at twice.Treatment courses for two groups continued 2 weeks.Record day/night cough symptoms scores, expectoration et accompanied symptoms scores, cough extinction time and cough disappeared rate after treatment.Adopt Leicester cough questionnaire (LCQ) to evaluate cough life quality. Result: The total effective rate of the observation group was 90.6% superior to 80.0% of the control group(P<0.05), after treatment, the integral of cough of daytime and night were both lower than than of the control group(P<0.01), the integral of accompanied symptoms such as cough and the total symptom integral were both lower than of the control group(P<0.01), the cough disappeared time of the observation group was (7.73±1.82) days were lower than (9.85±1.76) days of the control group (P<0.01), the disappearance rate of cough was 44.44% superior to 22.22% of the control group(P<0.05), the three dimension of LCQ scale such as physiological status, physiological health, society function and total grade were all higher than that of the control group(P<0.01). Conclusion: Qufeng Runfei Tongluo Zhike decoction which used in chronic cough can relief the main symptoms such as cough of the patients, improve quality of life of patients with cough, there was a significant clinical effect.