中药多靶点逆转肺癌多药耐药机制研究

Chinese Medicine Multi-target to Reverse MDR Mechanisms of Lung Cancer

摘要:

通过对近年国内外相关文献的查阅、分析，对中药单体及复方逆转肺癌多药耐药机制的研究情况进行介绍。目前中药单体及复方主要从下调膜转运蛋白、降低肿瘤细胞解毒、修复功能、影响信号转导凋亡调控基因、影响细胞周期、影响肿瘤细胞外基质等方面实现逆转肺癌多药耐药的作用；结果表明中药单体及复方通过多途径、多层次逆转肺癌多药耐药，逆转作用机制广泛，体现了中医药高效、低毒、多靶点的优势。但目前研究大多集中在中药单体成分、体外研究，中药复方及临床研究明显不足，而中医临床辨证用药及疗效的发挥大多是以中药复方为手段实现的。因此，充分运用现代分子生物学技术，着力中药复方逆转剂的研究更具临床应用价值；中医药必将在逆转肿瘤耐药，防治复发转移、延长生存期、提高患者生存质量方面发挥重要作用，为中医药临床治疗肺癌耐药提供科研依据。

Abstract:

Review and analysis the progress of research in traditional Chinese herbal monomer and compound reversing lung cancer multi-drug resistance (MDR) mechanisms.Currently, traditional Chinese herbal monomer and compound achieve reversal of multidrug resistance in lung cancer primarily by reducing membrane transport proteins, decreasing tumor cell detoxification, repair, regulating signal transduction apoptosis genes, cell cycle, tumor extracellular matrix. These results indicate that traditional Chinese herbal to reverse drug resistance mechanisms of lung cancer characterized by a multi-target, with potential development value, but also for the treatment of cancer in clinical medicine provides a scientific foundation.