中药纳米肝靶向给药系统的研究进展

New Progression of Chinese Medicine Nanoparticles Drug Delivery System in Hepatocellular Carcinoma

摘要:

通过查阅近几年文献，从被动靶向，主动靶向及物理化学靶向制剂三个方面对中药纳米靶向制剂在肝癌中的应用进行分析总结，重点介绍了中药纳米粒靶向治疗肝细胞癌的机制和方法，并对中药纳米肝靶向给药系统的前景进行了讨论与展望。肝细胞癌（HCC）是高发病率和死亡率的恶性肿瘤，临床上由于药物对肿瘤的选择性差，吸收率低和多药耐药的出现，肝癌患者的化疗效果并不理想。中药在治疗肝癌中具有特殊优势，纳米中药兼具中药与纳米的优势，有效地解决了上述问题，在肝癌的治疗中展现了丰富的应用前景，已成为肝癌靶向治疗研究中的热点。

Abstract:

In this paper, We performed a analysis andsummaryof numerous published papers about Chinese medicine NPs'targeted therapy in Hepatocellular carcinoma( HCC)from three aspects: focusing on the passive targeting, active targeting and physicochemical targetingagents, especially the mechanisms and methods. We also give a discussion and outlook about the further development of Chinese medicine NPs'drug delivery systems in HCC. (HCC) is a kind of malignancy with high morbidity and mortality, Due to the drug' poor selectivity to tumor, low absorption and the emergence of multidrug resistance clinically, the effect of chemotherapy in patients with liver cancer is not ideal. Where the chinese medicine play a significant role, The chinese medicine nanoparticles(NPs) combineing the advantages of nano-medicine and nano-medicine, solve the above problems effectively , show a wealth of potential applications in the treatment of liver cancer, and become the hot spot in HCC targeted therapy nowadays.