蜣螂壳聚糖游离膜的制备工艺优选

Preparation of Chitosan Film from Catharsius molossus

摘要:

目的：优选蜣螂壳聚糖膜的制备工艺。方法：以力学性能、透湿性、溶胀性、耐酸性为指标，采用单因素试验考察溶剂（乙酸）、脱膜剂（氢氧化钠）、增塑剂（甘油）、壳聚糖质量分数及干燥条件等因素对壳聚糖成膜的影响。结果：优选的制备工艺为2%乙酸，2%壳聚糖，2%氢氧化钠，脱膜时间2 h，5%甘油，成膜干燥温度40 ℃；制成的壳聚糖膜外观透明，厚薄均匀，透湿性小，具备一定的耐酸性，机械性能及综合性能良好。结论：该工艺稳定可行，为壳聚糖的药用包衣及工业化成膜提供参考。

Abstract:

Objective: To prepare chitosan film as a carrier of colon-specific drug delivery system from Catharsius molossus. Method: Taking mechanical properties, moisture penetrability, swelling and acid resistance as indexes, single factor tests were adopted to optimize preparation technology with concentrations of acetic acid, glycerol and sodium hydroxide, drying conditions as factors. Result: The best process of film-forming were as follows:2% acetic acid as solvent, the concentration of chitosan 2%, 2% sodium hydroxide as de-film agent, immersion time of 2 h, 5% glycerol as plasticizer;Chitosan solution on glass plate was heated for 3 h at 40 ℃ firstly in process of film-forming, these prepared chitosan film had transparent appearance, uniform thickness, small moisture permeability and some resistance to acid with good mechanical properties and overall performance. Conclusion: This technology was stable and reliable, it could be used as a coating excipient in colon-specific tablets and may have wide application in other fields as a new material.