麻杏石甘汤平喘量-效关系研究

Dose-effect Relationship of Maxing Shigan Decotion in Anti-asthmatic Effects

摘要:

目的：探讨麻杏石甘汤（MXSGT）治疗支气管哮喘的量-效关系，为其临床用药的合理性提供实验依据，并初步揭示中药复方量-效关系的特征。方法：采用生物信号采集系统，记录、分析9个剂量组MXSGT对磷酸组胺引喘豚鼠哮喘潜伏期、哮喘持续时间的影响，以剂量为横坐标、效应为纵坐标绘制其剂量-效应曲线，并经多元线性回归分析初步探讨MXSGT平喘的量-效关系。结果：MXSGT（以生药量计）1.33，3.0，10.13 g·kg^-1剂量组均可明显延长引喘潜伏期（P<0.05），对引喘潜伏期影响的量-效关系方程为Y=86.31+1.2X-0.063X²；MXSGT各剂量组均能明显缩短哮喘持续时间（P<0.05或P<0.01），对哮喘持续时间影响的量-效关系方程为Y=13.99+0.44X-0.014X²。结论：MXSGT的平喘作用属于非线性的量-效关系，随着整方剂量的增加，对哮喘动物模型效应指标的影响呈波浪形变化趋势。

Abstract:

Objective: To discuss the dose-effect relationship of maxingshigan decotion (MXSGD) in anti-asthmatic effects, and reveal characteristics of dose-effect relationship of Chinese compound preliminarily. Method: The influences of the 9 dose groups of MXSGD on the histamine phosphate induced asthma in guinea pigs were recorded and analyzed by the biological signal collection system, its dose-response curve was drawn in a dose as abscissa, effect as ordinate and the dose-effect relationship of multiple linear regression analysis. Result: MXSGD 1.33, 3.0, 10.13 g·kg^-1 could significantly prolong the incubation period of asthma (P<0.05), the dose-effect relationship between the asthma incubation period of equationwas Y=86.31+1.2X-0.063X²;MXSGD could significantly shorten the duration of asthma (P<0.05 or P<0.01), the dose-effect relationship equation asthma duration effect Y=13.99+0.44X-0.014X². Conclusion: The dose-effect relationship of maxingshigan decotion in anti-asthmatic effects is a non-linear, with the increase of the dose, indexes of effect on asthma animal model is increased.