南川木波罗根皮的化学成分

Chemical Constituents Occurring in Roots of Artocarpus nanchuanensis

摘要:

目的: 研究南川木波罗根皮的化学成分.方法: 采用硅胶、Diaion HP20大孔吸附树脂、MCI gel CHP 20P树脂凝胶、Sephadex LH-20凝胶、ODS等柱色谱分离手段,对南川木波罗根皮醇提物的乙酸乙酯部位进行化学成分的分离纯化,根据化合物的理化性质及光谱数据鉴定其结构.结果: 分离了9个化合物,分别鉴定为4-羟基苯甲醛(p-hydroxybenzaldehyde)(1), 2,4-二羟基苯甲酸(2,4-dihydroxybenzoic acid)(2), 香豆酸 (p-coumaric acid)(3), 儿茶素[(+) catechin](4), (E)-阿魏酸甲酯[(E)-ferulic acid methyl ester](5), E-对-羟基肉桂酸甲酯(p-E-hedroxycinnamic acid methyl ester)(6), norartocarpetin(7), 反式氧化白黎芦醇(trans-oxyresveratrol)(8), moracin M(9).结论: 化合物1,2,5,6为首次从桑科植物中获得,化合物3为首次在波罗蜜属植物中发现,而化合物7~9为首次从南川木波罗中分离得到.

Abstract:

Objective:To study the chemical constituents of roots of Artocarpus nanchuanensis. Method: The constituents were isolated from the ethyl acetate portion of 95% ethanol extraction of A. nanchuanensis roots by column chromatography over silica gel, Diaion HP20 macroreticular resin, MCI CHP 20P gel, Sephadex LH-20 gel, ODS gel, etc. Their structures were elucidated by analysis of physical chemical properties and spectral data. Result: Nine compounds were isolated and their structures were identified as p-hydroxybenzaldehyde(1), 2, 4-dihydroxybenzoic acid(2), p-coumaric acid(3), (+) catechin(4), (E)-ferulic acid methyl ester(5), p-E-hedroxycinnamic acid methyl ester(6), norartocarpetin(7), trans-oxyresveratrol(8), moracin M(9). Conclusion: Compounds 1, 2, 5 and 6 were isolated from Moraceae for the first time. Compound 3 was firstly reported the occurrence in the genus Artocarpus, and compounds 7-9 were characterized in A. nanchuanensis for the first time.