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消麻止痛胶囊对糖尿病周围神经病变患者神经传导速度的改善作用及机制
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湖南省教育厅资助科研项目(11C0971)


Improvement and Mechanism of Xiaoma Zhitong Capsule on Nerve Conduction Velocity in Patients with Diabetic Peripheral Neuropathy
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    摘要:

    目的: 探讨消麻止痛胶囊对糖尿病周围神经病变(diabetic peripheral neuropathy, DPN)患者神经传导速度的改善作用及其作用机制.方法: 将收治的102例糖尿病周围神经病变患者随机分为对照组50例和治疗组52例,对照组患者给予口服甲钴胺500 mg和安慰剂,3次/d;治疗组口服甲钴胺500 mg,3次/d和消麻止痛胶囊4粒,3次/d,连续治疗4周为1个疗程.3个疗程后评价疗效,测定患者正中神经、腓总神经运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)的变化,对醛糖还原酶(AR),一氧化氮(NO)和超氧化物歧化酶(SOD)活性的变化进行比较,并通过多伦多临床神经病变评分(toronto clinical scoring system, TCSS)症状评分和VAS疼痛评分对病情进行评估.结果: 治疗组总有效率为90.4%,明显优于对照组(74.0%),差异有统计学意义(P<0.05);两组患者治疗后MNCV和SNCV较治疗前均有所提高,其中治疗组比较差异有统计学意义(P<0.05);治疗组AR水平明显降低(P<0.05),NO和SOD升高显著(P<0.05),且治疗组AR,NO和SOD水平与对照组比较差异有统计学意义(P<0.05);治疗后对照组和治疗组TCSS评分分别为(6.27±1.17)分和(4.52±0.93)分,VAS评分为(5.33±0.64)分和(4.26±0.53)分,治疗组明显低于对照组,差异有统计学意义(P<0.05).结论: 消麻止痛胶囊联合甲钴胺可明显改善DPN患者的神经传导速度,有助于糖尿病周围神经病变的治疗,这可能与患者体内AR,NO和SOD活性的变化有关.

    Abstract:

    Objective:To investigate the effect and mechanism of Xiaoma Zhitong capsule on nerve conduction velocity in the treatment of diabetic peripheral neuropathy(DPN). Method: One hundred and two patients were randomly divided into control group(50 cases)and observation group(52 cases). The patients in control group received 500 mg methycobal and placebo 3 times daily, and the patients in observation group received 500 mg methycobal 3 times daily and Xiaoma Zhitong capsules 4 times daily. Patients in both groups received a 3 4-week periods of treatment. Curative effect, motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)in two groups were observed, activity of aldose reductase(AR), nitric oxide(NO)and superoxide dismutase(SOD)were compared between two groups. The curative effect was evaluated by toronto clinical scoring system(TCSS)and visual analogue score(VAS). Result: The total effective rate of control group was 90.4%, which was higher than control group(74.0%, P<0.05). MNCV and SNCV of patients in two groups were improved after treatment, and there was statistically significant difference in the observation group(P<0.05). Levels of AR were decreased(P<0.05), NO and SOD were increased(P<0.05)in the observation group as compared with the control group(P<0.05). TCSS score in control group and treatment group were(6.27±1.17), and(4.52±0.93), respectively. VAS score in control group and treatment group was(5.33±0.64)and (4.26±0.53), respectively. and the observation group had lower results(P<0.05). Conclusion: Using Xiaoma Zhitong capsule combined with methycobal had definite curative effect on diabetic peripheral neuropathy, it could obviously improve the peripheral neuropathy of diabetic patients. The effect may be related to regulating the activities of AR, NO and SOD.

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周月红,段春艳,廖尚上,莫小书,喻红.消麻止痛胶囊对糖尿病周围神经病变患者神经传导速度的改善作用及机制[J].中国实验方剂学杂志,2014,20(22):189~193

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  • 收稿日期:2013-12-18
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  • 在线发布日期: 2014-11-07
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