黑骨藤中神经酰胺类化学成分

Ceramides of Periploca forrestii

摘要:

目的: 研究黑骨藤化学成分. 方法: 采用反复硅胶柱色谱法、Sephadex LH-20柱色谱法等进行分离纯化,并通过理化常数测定和质谱、一维、二维核磁共振等波谱方法分析鉴定其化学结构. 结果: 从黑骨藤中分离鉴定了2个神经酰胺类化合物,分别为1-O-β-D-葡萄糖-(2S, 3S, 4R, 10E)-2-[(2R)-2-羟基二十四烷酰氨基]-10-十八烷-3, 4-二醇(1),(2S, 3S, 4R, 10E)-2-[(2R)-2-羟基二十四烷酰氨基]-10-十八烷-1, 3, 4-三醇(2). 结论: 所有化合物均首次从黑骨藤中分离得到,采用二维核磁技术确定化合物2的结构,并对其二维谱数据进行归属.

Abstract:

Objective: To study chemical constituents of Periploca forrestii. Method: Many kinds of chromatographic methods were used in the isolation procedure, while the structures of compounds were elucidated by physical and chemical properties and MS, 1 D, 2 D NMR techniques. Result: Two known compounds were isolated from P. forrestii. Identified as 1-O-β-D-glucopyranosyl- (2S, 3S, 4R, 10E)-2-[(2R)- 2-hydroxytetra cosanoylamino]-10- octadecene-3, 4-diol(1), (2S, 3S, 4R, 10E)-2-[(2R)-2- hydroxytetra cosanoylamino] -10 -octadecene-1, 3, 4-triol(2). Conclusion: Two compounds were all isolated from P.forrestii for the first time.