抑肝散神经保护物质基础

Neuroprotective Material Base of Yigan San

摘要:

目的: 研究中药复方抑肝散活性部位的化学物质基础,为阐明其药理作用机制提供理论依据. 方法: 应用各种色谱和光谱方法,对抑肝散活性部位的化学成分进行分离和鉴定. 结果: 从抑肝散活性部位中分离得到15个化合物,分别鉴定为卡达宾(1),钩藤碱(2),甘草苷(3),甘草素(4),异甘草苷(5),异甘草素(6),saikochromoside A(7),汉黄芩苷(8),芒柄花苷(9),tetrahydroxymethoxychalcone(10),槲皮素(11),山奈酚(12),洋川芎内酯Ⅰ(13),洋川芎内酯H(14) 和阿魏酸(15). 结论: 以上化合物均为首次从抑肝散活性部位中分离得到.

Abstract:

Objective: To investigate the material base of Yigan San, a Chinese herbal formula for Alzheimer's disease, and to provide theoretical foundation for the explanation of pharmacological mechanism. Method: The chemical constituents were isolated and identified by various chromatographic and spectral methods. Result: Fifteen compounds were isolated and identified as cadambine(1), rhynchophyline(2), liquiritin(3), liquiritigenin(4), isoliquiritin(5), isoliquiritgenin(6), saikochromoside A(7), wogonin-7-O-glucuronide(8), ononin(9), tetrahydroxymethoxychalcone(10), quercetin(11), kaempferol(12), senkyunolide I(13), senkyunolide H(14), and ferulic acid(15), respectively. Conclusion: All these compounds were isolated from the active fraction of Yigan San for the first time.